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Current Developments in Biotechnology and Bioengineering: Human and Animal Health Applications
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Turley Director. Human Cells. Our Pipeline. Precision immunology for developing gene and cell therapies. Therapeutic Area. Phase 1. New class of microbe-based biopharmaceuticals to enable local delivery of disease-modifying human therapeutics. Phase 2. Targeted gene and cell therapies for unmet health needs. Gene Targeting. Food and Drug Administration for commercial research use in cardiovascular disease research.
This model features targeted disruption of the endogenous LDLR low-density lipoprotein receptor gene. Discover More. Commercial Research Stage. MiniSwine research models are more anatomically, physiologically, and genetically similar to humans than are mice and other small-animal disease models and are designed to provide improved predictive power to the preclinical stages of therapeutic development.
This should allow for the inducement of human-like tumors in a tissue specific manner. Food and Drug Administration for commercial use as a research model.
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This model features targeted disruption of the endogenous ATM gene in Yucatan MiniSwine genetics to generate a model that recapitulates ataxia telangiectasia AT , a rare inherited, predominantly neurological human disease. It offers a platform with greater anatomical, physiological, and genetic similarity to humans, mitigating the lack of translation with murine systems due to differences in size and metabolism, and can be used by researchers to help define and develop effective therapies for polycystic kidney disease.
The development of models of sickle cell disease is part of a subcontract with Leidos Biomedical Research, Inc. Microbe-based biotherapeutics to promote animal health.
Initial Screening. Methane bioconversion to generate high value fuels and chemicals from natural gas. Isobutanol has a market size of c. Isobutanol is an organic compound used as a clean burning drop-in fuel that can be blended with gasoline and is compatible with the existing petroleum infrastructure. In Development. Isobutyraldehyde is a chemical intermediate for methyl methacrylate which is principally used in the manufacture of plastics and has a market size of c. Farnesene is an industrial chemical compound that forms the basis for a wide range of products varying from specialty products such as cosmetics, perfumes, detergents and industrial lubricants, to transportation fuels such as diesel and jet fuel and has a market size of c.
Isoprene is a chemical intermediate used in the production of synthetic rubber and has a market size of c. Non-browning produce to benefit the food supply chain, from growers to consumers. In Market. Browning of avocado flesh after exposure to oxygen is a significant problem for producers and consumers. In collaboration with Persea Bio, intrexon is developing improved cultivation techniques and traits for avocados. Spiders that produce orb-webs synthesize as many as seven different types of silk for making these webs. One of the most durable varieties is dragline silk.
Its energy-absorbing capabilities exceed those of steel. There are numerous potential applications of these fibers in medical devices, sutures, ballistic protection, tire cord, air bags, aircraft, automotive composites, and clothing.
In using any new technology, there are problems that occur and there are risks to be considered. From the technical side, these problems can be: 1 unregulated expression of genes resulting in over- or underproduction of gene products; 2 too high a copy number resulting in overexpression of products; 3 possible side effects, e.
Many, if not all, of these problems are related to the transgene itself, integration site, copy number, and transgene expression. These issues can be addressed, at least in part, through construct design and testing. From the animal side, the welfare, biology, and health of the resulting transgenic animal must be of paramount concern.
From the consumer side, the food or agricultural product produced must be safe, wholesome, non-allergenic, nutritious, and economical. These are issues being addressed by various governmental agencies. The genetic engineering of livestock is a difficult task, and great care must be taken before such effort begins. Serious consideration is critical because of the time, cost, welfare, ethics, risks, and benefits involved in these kinds of projects. However, farmers, consumers, and scientists all want safe food, which means that animal care, animal health, animal welfare, public concern, ethics, and societal benefit and vigilance cannot be ignored.
On the contrary, these concerns should be welcomed when designing and conducting such projects. Consideration of these as well as scientific issues will lead us forward toward harvesting the bounty promised by this important technology. Boroola fecundity FecB gene : A single major autosomal gene for fecundity in Merino sheep. Creutzfeldt-Jacob disease CJD : A progressive neurological disease in humans caused by a transmissible agent known as a prion.
EGF : Epidermal growth factor, which is a growth factor involved in cell growth, proliferation, and differentiation. IGF-I : Insulin-like growth factor-I, which is a growth factor involved in neonatal growth and anabolic growth in adults. This is the same disease as bovine spongiform encephalopathy BSE. Staphylococcus aureus : A gram-positive bacterium that is a major causative agent of mastitis in cattle. Such an organism is able to pass the transgene on to all the offspring. It should be stressed that all the cells of a transgenic individual contain the transgene.
Also, the original transgenic individual had the foreign DNA inserted into the one-cell embryo via a laboratory technique, such as pronuclear injection.
It could be a microbe, plant, or animal. Devlin, R. Production of germline transgenic Pacific salmonids with dramatically increased growth performance. Canadian Journal of Fisheries and Aquatic Sciences 52 , Extraordinary salmon growth . Nature , Donovan, D. Engineering disease resistant cattle. Transgenic Research 14 , Dunham, R. Comparison of traditional breeding and transgenesis in farmed fish with implications for growth enhancement and fitness.
Transgenic Animals in Agriculture , Ebert, K. Porcine growth hormone gene expression from viral promoters in transgenic swine. Animal Biotechnology 1 , A Moloney MLV-rat somatotropin fusion gene produces biologically active somatotropin in a transgenic pig. Molecular Endocrinology 2 , Golding, M. Suppression of prion protein in livestock by RNA interference. Golovan, S. Pigs expressing salivary phytase produce low-phosphorus manure.
Nature Biotechnology 19 , Grosvenor, C. Hormones and growth factors in milk. Endocrinology Reviews 14 , Hollis, D.rupmarktefido.ga
Current Developments in Biotechnology and Bioengineering - 1st Edition
Morphological changes in the skin and wool fibres of Merino sheep infused with mouse epidermal growth factor. Australian Journal of Biological Sciences 36 , Karatzas, C. Transgenic Research 8 , Lai, L.
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